Steven Perry

Biography

Selected Publications

• Fatty acids negatively regulate platelet function through formation of noncanonical 15-lipoxygenasederived eicosanoids, Pharmacology Research and Perspectives, 2023, Jan 28; e01056, Yamaguchi A, van Hoorebeke C, Tourdot BE, Perry SC, Lee G, Rhoads N, Green AR, Sorrentino J, Yeung J, Freedman J, Holinstat M, Holman TR

• Structural basis for altered positional specificity of 15-lipoxygenase-1 with 5S-HETE and 7S-HDHA and the implications for the biosynthesis of resolvin E4, Archives of Biochemistry and Biophysics, 2022, Sep 30; 727:109317, Perry SC, van Hoorebeke C, Sorrentino J, Bautista L, Akinkugbe O, Conrad WS, Rutz N, Holman TR

• Role of Human 15-Lipoxygenase-2 in the biosynthesis of the lipoxin intermediate, 5S,15S-diHpETE, implicated with altered positional specificity of 15-Lipoxygenase-1, Biochemistry, 2020; 59(42): 4118-4130, Perry SC, Horn T, Tourdot B, Yamaguchi A, Kalyanaraman C, Conrad W, Akinkugbe O, Holinstat M, Jacobson MP, Holman TR.

• 15-Lipoxygenase-1 biosynthesis of 7S,14S-diHDHA implicates 15-Lipoxygenase-2 in biosynthesis of resolvin D5 J. of Lipid Research, 2020;61(7):1087-1103, Perry SC, Kalyanaraman C, Tourdot BE, Conrad WS, Akinkugbe O, Freedman JC, Holinstat M, Jacobson MP, Holman TR.

• N-acetylcysteine targets 5 lipoxygenase-derived, toxic lipids and can synergize with PGE2 to inhibit ferroptosis and improve outcomes following hemorrhagic stroke in mice, Annals of Neurology, 2018 Oct 7, Karuppagounder SS, Dietrich K, Alin L, Chen Y, Brand D, Bourassa MW, Perry S, John Pinto J, Darley-Usmar V, Milne G, Domenico P, Holman TR, Carmichael T, Coppola G, Colbourne F, Ratan RR

• An extracellular biochemical screen reveals that FLRTs and Unc5s mediate neuronal subtype recognition in the retina, eLife, 2015;10.7554/eLife.08149, Visser J, Cheng Y, Perry S, Chastain A, Parsa B, Masri S, Kay J, Wojtowicz W

• Potent and Selective Inhibitors of Human Reticulocyte 12/15- Lipoxygenase as Anti-Stroke Therapies, J. of Medicinal Chemistry, 2014 Mar 31., Holman TR, Maloney DJ, Rai G, Yasgar A, Simeonov A, Jadhav A, Joshi N, Perry S, Diaz G, Kenyon V, van Leyen K, Zhang Q, Schultz L, Jung JE, Liu Y, Lo E.

• Discovery of a novel dual fungal CYP51/human 5-lipoxygenase inhibitor: Implications for anti-fungal therapy, PLoS One, 2013 Jun 24, 8(6): e65928, Hoobler EK, Rai G, Warrilow AGS, Perry SC, Smyrniotis CJ, Jadhav A, Simeonov A, Parker JE, Kelly DE, Maloney DJ, Kelly SL, Holman TR

Educational Background

• Ph.D., Chemistry and Biochemistry, University of California, Santa Cruz, 2019

• B.S., Ecology and Evolutionary Biology, University of California, Santa Cruz, 2008

• A.A., History, A.A. Psychology: Foothill College,